Grave Robber (Terrance Zdunich) holding a "little glass vial" of Zydrate. Notice the blue, glowing color, indicative of street zydrate. To use Zydrate, Grave Robber instructs "the little glass vial goes into the gun like a battery/ And the Zydrate gun goes somewhere against your anatomy/ And when the gun goes off, it sparks and you're ready for surgery..."

Zydrate is a highly addictive painkiller. Zydrate sold by GeneCo is quite expensive, but it has a cheaper, illegal counterpart on the black market, extracted from the dead. It is a blue, glowing liquid, stored most frequently in a little glass vial. Zydrate is administered via a Zydrate gun, usually to the inner thigh or shoulder, indicating it is most effective when injected into a muscle.

According to interviews and bonus material, Zydrate mimics the effect of “going into the light”, creating an extremely euphoric high. The posited reason for this is that the human body originally produce the chemical slightly before or after death, allowing it to be extracted from the dead; however, this extraction could likely also be possible due to the deceased already having Zydrate in their system. GeneCo learned to synthesize and concentrate the chemical, which is likely one of the many reasons it’s so expensive when purchased directly and “legally”.

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